The Inside Track: Privileged Neural Communication through Axon-Carrying Dendrites
نویسندگان
چکیده
Whether morphology tailors functional properties of pyramidal neurons is not completely understood. In this issue of Neuron, Thome et al. (2014) show that, in hippocampal pyramidal neurons, axons frequently originate from basal dendrites rather than the soma, constituting a "privileged" channel for synaptic inputs located in these axon-carrying dendrites.
منابع مشابه
Axon-Carrying Dendrites Convey Privileged Synaptic Input in Hippocampal Neurons
Neuronal processing is classically conceptualized as dendritic input, somatic integration, and axonal output. The axon initial segment, the proposed site of action potential generation, usually emanates directly from the soma. However, we found that axons of hippocampal pyramidal cells frequently derive from a basal dendrite rather than from the soma. This morphology is particularly enriched in...
متن کامل/ 4 Lecture 8 : Artificial neural networks
The brain is composed of about 10 neurons (nerve cells) of many different types. Fig.1 is a schematic drawing of a single neuron. Tree-like networks of nerve fiber called dendrites are connected to the cell body (or soma) where the cell nucleus is located. Extending from the cell body is a single long fiber called the axon, which usually branches into many strands, at the ends of which are the ...
متن کاملMachine Learning , Foundations Spring Semester , 2003 / 4 Lecture 8 : Artificial neural networks
The brain is composed of about 10 neurons (nerve cells) of many different types. Fig.1 is a schematic drawing of a single neuron. Tree-like networks of nerve fiber called dendrites are connected to the cell body (or soma) where the cell nucleus is located. Extending from the cell body is a single long fiber called the axon, which usually branches into many strands, at the ends of which are the ...
متن کاملAxon guidance
The nervous system has the job of controlling and monitoring events throughout the whole body. But, unlike endocrine cells, which control their targets through long-range chemical cues, neurons communicate through direct cellular contacts, or synapses. As the information content of the electrical signals used by neurons is limited, much of the meaning in neural communication is conveyed by the ...
متن کاملDifferential trafficking of transport vesicles contributes to the localization of dendritic proteins.
In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown. Here, we use a novel pulse-chase system, which allows synchronous release of exogenous transmembrane proteins from the endoplasmic reticulum to follow movements of post-Golgi transport v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuron
دوره 83 شماره
صفحات -
تاریخ انتشار 2014